Bondia™ is a novel, clinically-validated medical food for bone loss. Made from 7 natural ingredients, Bondia™‘s innovative formulation harnesses fruit and vegetable microbes to support bone mineral density.
Preclinical studies demonstrated that daily oral consumption of Bondia™ helped slow bone loss and, as a result, improved overall bone density compared to control. The clinical study validated the preclinical studies and is currently pending peer review and publication.
Preclinical results of Bondia™
Preclinical Trial Results
Results of Bondia™
Through preclinical testing, Bondia™ was shown to reduce bone loss by 40-60% in a post-menopausal model. Bondia™ was also validated to improve bone maintenance and reduce osteoclastic production.
As Bondia™ is a medical food, it is labeled for consumption under the guidance of a physician. It was proven to be safe and well-tolerated through a randomized, double-blind, placebo-controlled clinical medical food trial in 32 healthy adults.
Bondia™ is made from natural ingredients, is generally recognized as safe (GRAS), and is not contraindicated for any medications or other substances.
Bondia™ can be safely consumed by anyone who is concerned about addressing bone loss, and is labeled for consumption under the guidance of a physician.
In the first week of use, users should take 1 Bondia™ capsule with breakfast and 1 capsule with dinner. In the second week and beyond, users can take 2 capsules with breakfast and 2 capsules with dinner. Users are advised to store Bondia™ in the refrigerator and keep it dry to maintain its potency.
Bondia™ can be ordered online, and is delivered on a recurring basis.
Bondia™ is labeled for consumption under the guidance of a physician. Patients who are breastfeeding, pregnant, or expecting to become pregnant should speak with a doctor before starting Bondia™.
Patients with osteoporosis can safely take Bondia™, though they should consult their doctor for their care.
A total of 286 early post-menopausal women ages 40-65 were enrolled in the Bondia clinical trial from November 2022 to July 2023. The randomized, double-blind, placebo-controlled clinical food trial was completed in July 2024 and is currently pending peer review and publication.
In the first week of use, users should take 1 Bondia™ capsule with breakfast and 1 capsule with dinner. In the second week and beyond, users should take 2 capsules with breakfast and 2 capsules with dinner. Please store Bondia™ in the refrigerator and keep dry to maintain its potency.
Bondia™ is natural, plant-derived, and made with only 7 ingredients: 4 probiotic strains (Lactiplantibacillus plantarum SBS04260, Levilactobacillus brevis SBS04254, Leuconostoc mesenteroides SBS04255, and Pichia kudriavzevii SBS04263), 2 prebiotic fibers (powdered organic blueberry and oligofructose), and a vegan capsule.
Bondia™ is not a drug or a dietary supplement—it’s a medical food. Medical foods deliver essential nutritional support for health conditions that can’t be addressed through diet alone. Though not a requirement, we validate all our medical foods using clinical testing with the same rigor as pharmaceutical products. Bondia™'s probiotics are natural, safe to consume, and do not require a prescription.
As Bondia™ is a medical food, it does not require a prescription, but is intended to be consumed under the guidance of a physician.
Bondia™ is generally recognized as safe (GRAS). In clinical trials, Bondia™ demonstrated similar side effects to those seen in the placebo group, indicating that it is very safe and well tolerated. A small percentage of users may experience mild and temporary digestive symptoms, such as increased gas, abdominal bloating, or occasional constipation. These effects typically subside as one’s body adjusts to the probiotics in Bondia™. Individual factors like diet and pre-existing digestive sensitivities may contribute. If symptoms persist, users should consult their healthcare provider to ensure that Bondia™ is right for them.
There is currently no evidence to suggest that Bondia™ interferes with common medications. However, as with any dietary supplement or medical food, we recommend that users consult their healthcare provider or pharmacist, especially if they are on multiple medications, to ensure that there are no interactions with any of their medications.
Common recommendations for supporting bone health include pharmaceutical treatments, vitamin D, calcium, weight-bearing exercise, and maintaining a balanced diet. Bondia™ capsules include vitamin D (800 IU per 4 capsules, or 133% of the recommended daily allowance). We recommend that users consult with their healthcare provider to develop a comprehensive approach tailored to their specific health needs.
Bondia™ has not been tested in women who are pregnant or breastfeeding. However, there is currently no evidence suggesting risks associated with taking probiotics during pregnancy or while breastfeeding. We strongly recommend that users consult with their healthcare provider or obstetrician before starting any new supplement or medical food during these periods to ensure that it aligns with their individual health needs.
In a clinical trial, participants who consumed Bondia™ twice-daily showed an improvement in bone mineral density compared to those taking a placebo, with results typically observable over a 12-month period. Some users may experience additional benefits sooner, such as improved digestive comfort, although bone health improvements generally take longer to become evident.
While Bondia™ is not FDA-approved in the same way that drugs are, it is classified as a medical food, and is specifically formulated for the dietary management of bone loss associated with menopause, weight, and age. Medical foods are regulated by the FDA, which ensures that Bondia™ adheres to strict safety, labeling, and manufacturing standards. Bondia™ is produced in FDA-compliant facilities, and all of its ingredients are generally recognized as safe (GRAS). Though not a requirement, Bondia™ has been validated using clinical testing with the same rigor as pharmaceutical products.
We recommend that users undergo a follow-up DEXA scan after using Bondia™ continuously for 12 months in order to assess any changes in bone mineral density. This time frame allows for the full benefits of Bondia™ to take effect. Maintenance of bone density should be compared to national averages of yearly bone loss for postmenopausal women.
We recommend taking Bondia™ with breakfast and dinner, as they are convenient times to remember. In Bondia™’s clinical study, participants took their capsules at least 6 hours apart each day, which is why we recommend that users space their consumption similarly—the exact times that users decide to take it can be flexible.
Some people may experience mild GI discomfort when consuming medications or supplements on an empty stomach, which is why we recommend taking Bondia™ with meals. However, Bondia™ can be taken without food depending on individual preference, as this is not believed to impact its effectiveness.
As demonstrated in its clinical study, Bondia™ was shown to be effective when taken twice daily. This allows the probiotics to remain active in one’s system throughout the day, ensuring optimal interaction with bone health and aligning with the regimen followed in Bondia™’s clinical trial. To help maintain this consistency, we recommend that users set a reminder to take Bondia™ each day.
If a user forgets to take Bondia™, they can take their next dose as soon as they remember. There’s no need to double up; users can simply resume their normal schedule moving forward. Ensuring that Bondia™ stays in their system continuously will allow them to maximize its benefits.
Bondia™ is designed to maintain its efficacy at room temperature for up to one month during active use. If stored for longer than a month at room temperature, the product's probiotic activity may begin to diminish. To preserve optimal potency, we recommend storing Bondia™ in a refrigerator when not in use.
If you have any questions about the science behind Bondia™, you can contact our team at info@journahealth.com. We’ll be happy to provide detailed answers regarding our clinical trials and research.
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